ISO 8262-1|IDF 124-1:2005 specifies the reference method for the determination of the fat content of infant foods to which the Röse-Gottlieb method is not applicable, i.e. those milk-based and other types of infant food that contain more than 5 % (mass fraction) (dry matter) of starch or dextrin, or vegetable, fruit, meat, etc.

The method is also applicable if the product contains free fatty acids in significant quantities or if hard lumps that do not dissolve completely in ammonia are present in the product.